AGON SR
Brand names,
AGON SR
Analogs
AGON SR
Brand Names Mixture
AGON SR
Chemical_Formula
C18H19Cl2NO4
AGON SR
RX_link
http://www.rxlist.com/cgi/generic2/felo.htm
AGON SR
fda sheet
AGON SR
msds (material safety sheet)
AGON SR
Synthesis Reference
P. B. Berntsson et al., U.S. Pat. 4,264,611 (1980)
AGON SR
Molecular Weight
384.253 g/mol
AGON SR
Melting Point
145oC
AGON SR
H2O Solubility
19.7 mg/L
AGON SR
State
Solid
AGON SR
LogP
4.121
AGON SR
Dosage Forms
Oral tablets
AGON SR
Indication
For the treatment of hypertension
AGON SR
Pharmacology
Felodipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Felodipine is similar to other peripheral vasodilators. Felodipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes blocking the calcium channels. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
AGON SR
Absorption
15%
AGON SR
side effects and Toxicity
excessive peripheral vasodilation with marked hypotension and possibly bradycardia
AGON SR
Patient Information
Information for the Patient
Patients should be instructed to take felodipine whole and not to crush or chew the
tablets. They should be told that mild gingival hyperplasia (gum swelling) has been
reported. Good dental hygiene decreases its incidence and severity.
Note: As with many other drugs, certain advice to patients being treated with felodipine
is warranted. This information is intended to aid in the safe and effective use of this
medication. It is not a disclosure of all possible adverse or intended effects.
AGON SR
Organisms Affected
Humans and other mammals