Penedil
Penedil Brand names, Penedil Analogs
- AGON SR
- Agon
- Dl-Felodipine
- FEXOFENADINE HCL
- Faropenem
- Feloday
- Felodipina [Inn-Spanish]
- Felodipine [Usan:Ban:Inn]
- Felodipinum [Inn-Latin]
- Felodur Er
- Felogard
- Fexofenadine Hydrochloride
- Fexofinadine Hcl
- Flodil
- Hydac
- Lexxel
- Modip
- Munobal
- Munobal Retard
- Penedil
- Perfudal
- Plandil
- Plendil
- Plendil Depottab
- Plendil Er
- Plendil Retard
- Preslow
- Prevex
- Renedil
- Splendil
Penedil Brand Names Mixture
- No information avaliable
Penedil Chemical_Formula
C18H19Cl2NO4
Penedil RX_link
http://www.rxlist.com/cgi/generic2/felo.htm
Penedil fda sheet
Penedil msds (material safety sheet)
Penedil Synthesis Reference
P. B. Berntsson et al., U.S. Pat. 4,264,611 (1980)
Penedil Molecular Weight
384.253 g/mol
Penedil Melting Point
145oC
Penedil H2O Solubility
19.7 mg/L
Penedil State
Solid
Penedil LogP
4.121
Penedil Dosage Forms
Oral tablets
Penedil Indication
For the treatment of hypertension
Penedil Pharmacology
Felodipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Felodipine is similar to other peripheral vasodilators. Felodipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes blocking the calcium channels. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Penedil Absorption
15%
Penedil side effects and Toxicity
excessive peripheral vasodilation with marked hypotension and possibly bradycardia
Penedil Patient Information
Information for the Patient
Patients should be instructed to take felodipine whole and not to crush or chew the
tablets. They should be told that mild gingival hyperplasia (gum swelling) has been
reported. Good dental hygiene decreases its incidence and severity.
Note: As with many other drugs, certain advice to patients being treated with felodipine
is warranted. This information is intended to aid in the safe and effective use of this
medication. It is not a disclosure of all possible adverse or intended effects.
Patients should be instructed to take felodipine whole and not to crush or chew the
tablets. They should be told that mild gingival hyperplasia (gum swelling) has been
reported. Good dental hygiene decreases its incidence and severity.
Note: As with many other drugs, certain advice to patients being treated with felodipine
is warranted. This information is intended to aid in the safe and effective use of this
medication. It is not a disclosure of all possible adverse or intended effects.
Penedil Organisms Affected
Humans and other mammals
