Fexofenadine Hydrochloride

Fexofenadine Hydrochloride Brand names, Fexofenadine Hydrochloride Analogs

Fexofenadine Hydrochloride Brand Names Mixture

Allegra-D (Fexofenadine hydrochloride + Pseudoephedrine hydrochloride)

Fexofenadine Hydrochloride Chemical_Formula

C₃₂H₃₉NO₄

Fexofenadine Hydrochloride RX_link

http://www.rxlist.com/cgi/generic/fexofen.htm

Fexofenadine Hydrochloride fda sheet

Fexofenadine_Hydrochloride FDA

Fexofenadine Hydrochloride msds (material safety sheet)

Fexofenadine Hydrochloride Synthesis Reference

S. H. Kawai et al., J. Org. Chem. 59, 2620 (1994)

Fexofenadine Hydrochloride Molecular Weight

501.656 g/mol

Fexofenadine Hydrochloride Melting Point

142.5 ^oC

Fexofenadine Hydrochloride H₂O Solubility

Slightly soluble

Fexofenadine Hydrochloride State

Solid

Fexofenadine Hydrochloride LogP

6.759

Fexofenadine Hydrochloride Dosage Forms

Oral tablets; Capsules

Fexofenadine Hydrochloride Indication

For management of Seasonal allergic rhinitis

Fexofenadine Hydrochloride Pharmacology

Fexofenadine is a second-generation, long lasting H1-receptor antagonist (antihistamine) which has a selective and peripheral H1-antagonist action. Histamine is a chemical that causes many of the signs that are part of allergic reactions, for example, swelling of tissues. Histamine is released from histamine-storing cells (mast cells) and attaches to other cells that have receptors for histamine. The attachment of the histamine to the receptors causes the cell to be "activated," releasing other chemicals which produce the effects that we associate with allergy. Fexofenadine blocks one type of receptor for histamine (the H1 receptor) and thus prevents activation of cells by histamine. Unlike most other antihistamines, Fexofenadine does not enter the brain from the blood and, therefore, does not cause drowsiness. Fexofenadine lacks the cardiotoxic potential, since it does not block the potassium channel involved in repolarization of cardiac cells.

Fexofenadine Hydrochloride Absorption

33%

Fexofenadine Hydrochloride side effects and Toxicity

Side effects include dizziness, drowsiness, and dry mouth.

Fexofenadine Hydrochloride Patient Information

Patients taking ALLEGRA tablets should receive the following information:

ALLEGRA tablets are prescribed for the relief of symptoms of seasonal allergic rhinitis or for the relief of symptoms of chronic idiopathic urticaria (hives). Patients should be instructed to take ALLEGRA only as prescribed. Do not exceed the recommended dose. If any untoward effects occur while taking ALLEGRA, discontinue use and consult the doctor.

The product should not be used by patients who are hypersensitive to it or to any of its ingredients.

Patients should be told that this product should be used in pregnancy or lactation only if the potential benefit justifies the potential risk to the fetus or nursing infant.

Patients should be advised to take the tablet with water. Patients should also be advised to store the medication in a tightly closed container in a cool, dry place, away from children.

Fexofenadine Hydrochloride Organisms Affected

Humans and other mammals