Plendil
Plendil Brand names, Plendil Analogs
- AGON SR
- Agon
- Dl-Felodipine
- FEXOFENADINE HCL
- Faropenem
- Feloday
- Felodipina [Inn-Spanish]
- Felodipine [Usan:Ban:Inn]
- Felodipinum [Inn-Latin]
- Felodur Er
- Felogard
- Fexofenadine Hydrochloride
- Fexofinadine Hcl
- Flodil
- Hydac
- Lexxel
- Modip
- Munobal
- Munobal Retard
- Penedil
- Perfudal
- Plandil
- Plendil
- Plendil Depottab
- Plendil Er
- Plendil Retard
- Preslow
- Prevex
- Renedil
- Splendil
Plendil Brand Names Mixture
- No information avaliable
Plendil Chemical_Formula
C18H19Cl2NO4
Plendil RX_link
http://www.rxlist.com/cgi/generic2/felo.htm
Plendil fda sheet
Plendil msds (material safety sheet)
Plendil Synthesis Reference
P. B. Berntsson et al., U.S. Pat. 4,264,611 (1980)
Plendil Molecular Weight
384.253 g/mol
Plendil Melting Point
145oC
Plendil H2O Solubility
19.7 mg/L
Plendil State
Solid
Plendil LogP
4.121
Plendil Dosage Forms
Oral tablets
Plendil Indication
For the treatment of hypertension
Plendil Pharmacology
Felodipine, a dihydropyridine calcium-channel blocker, is used alone or with an angiotensin-converting enzyme inhibitor, to treat hypertension, chronic stable angina pectoris, and Prinzmetal's variant angina. Felodipine is similar to other peripheral vasodilators. Felodipine inhibits the influx of extra cellular calcium across the myocardial and vascular smooth muscle cell membranes blocking the calcium channels. The decrease in intracellular calcium inhibits the contractile processes of the myocardial smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.
Plendil Absorption
15%
Plendil side effects and Toxicity
excessive peripheral vasodilation with marked hypotension and possibly bradycardia
Plendil Patient Information
Information for the Patient
Patients should be instructed to take felodipine whole and not to crush or chew the
tablets. They should be told that mild gingival hyperplasia (gum swelling) has been
reported. Good dental hygiene decreases its incidence and severity.
Note: As with many other drugs, certain advice to patients being treated with felodipine
is warranted. This information is intended to aid in the safe and effective use of this
medication. It is not a disclosure of all possible adverse or intended effects.
Patients should be instructed to take felodipine whole and not to crush or chew the
tablets. They should be told that mild gingival hyperplasia (gum swelling) has been
reported. Good dental hygiene decreases its incidence and severity.
Note: As with many other drugs, certain advice to patients being treated with felodipine
is warranted. This information is intended to aid in the safe and effective use of this
medication. It is not a disclosure of all possible adverse or intended effects.
Plendil Organisms Affected
Humans and other mammals
