Loxapine
Loxapine Brand names, Loxapine Analogs
Loxapine Brand Names Mixture
- No information avaliable
Loxapine Chemical_Formula
C18H18ClN3O
Loxapine RX_link
http://www.rxlist.com/cgi/generic2/loxapineoc.htm
Loxapine fda sheet
Loxapine msds (material safety sheet)
Loxapine Synthesis Reference
Neth. pat. Appl. 6,406,089 corresp to Schmutz et al., U.S. pat. 3,546,226 (1964, 1970 both to Wander)
Loxapine Molecular Weight
327.808 g/mol
Loxapine Melting Point
109-110 oC
Loxapine H2O Solubility
No information avaliable
Loxapine State
Solid
Loxapine LogP
3.162
Loxapine Dosage Forms
Tablet; Capsule; Oral solution; IV solution; IM solution
Loxapine Indication
For the management of the manifestations of psychotic disorders
Loxapine Pharmacology
Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established.
Loxapine Absorption
Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers
Loxapine side effects and Toxicity
LD50=65 mg/kg (Orally in mice)
Loxapine Patient Information
Loxapine Organisms Affected
Humans and other mammals
