Loxitane Im
Brand names,
Loxitane Im
Analogs
Loxitane Im
Brand Names Mixture
Loxitane Im
Chemical_Formula
C18H18ClN3O
Loxitane Im
RX_link
http://www.rxlist.com/cgi/generic2/loxapineoc.htm
Loxitane Im
fda sheet
Loxitane Im
msds (material safety sheet)
Loxitane Im
Synthesis Reference
Neth. pat. Appl. 6,406,089 corresp to Schmutz et al., U.S. pat. 3,546,226 (1964, 1970 both to Wander)
Loxitane Im
Molecular Weight
327.808 g/mol
Loxitane Im
Melting Point
109-110 oC
Loxitane Im
H2O Solubility
No information avaliable
Loxitane Im
State
Solid
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LogP
3.162
Loxitane Im
Dosage Forms
Tablet; Capsule; Oral solution; IV solution; IM solution
Loxitane Im
Indication
For the management of the manifestations of psychotic disorders
Loxitane Im
Pharmacology
Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established.
Loxitane Im
Absorption
Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers
Loxitane Im
side effects and Toxicity
LD50=65 mg/kg (Orally in mice)
Loxitane Im
Patient Information
Loxitane Im
Organisms Affected
Humans and other mammals