Loxapina [Inn-Spanish]
Brand names,
Loxapina [Inn-Spanish]
Analogs
Loxapina [Inn-Spanish]
Brand Names Mixture
Loxapina [Inn-Spanish]
Chemical_Formula
C18H18ClN3O
Loxapina [Inn-Spanish]
RX_link
http://www.rxlist.com/cgi/generic2/loxapineoc.htm
Loxapina [Inn-Spanish]
fda sheet
Loxapina [Inn-Spanish]
msds (material safety sheet)
Loxapina [Inn-Spanish]
Synthesis Reference
Neth. pat. Appl. 6,406,089 corresp to Schmutz et al., U.S. pat. 3,546,226 (1964, 1970 both to Wander)
Loxapina [Inn-Spanish]
Molecular Weight
327.808 g/mol
Loxapina [Inn-Spanish]
Melting Point
109-110 oC
Loxapina [Inn-Spanish]
H2O Solubility
No information avaliable
Loxapina [Inn-Spanish]
State
Solid
Loxapina [Inn-Spanish]
LogP
3.162
Loxapina [Inn-Spanish]
Dosage Forms
Tablet; Capsule; Oral solution; IV solution; IM solution
Loxapina [Inn-Spanish]
Indication
For the management of the manifestations of psychotic disorders
Loxapina [Inn-Spanish]
Pharmacology
Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established.
Loxapina [Inn-Spanish]
Absorption
Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers
Loxapina [Inn-Spanish]
side effects and Toxicity
LD50=65 mg/kg (Orally in mice)
Loxapina [Inn-Spanish]
Patient Information
Loxapina [Inn-Spanish]
Organisms Affected
Humans and other mammals