Loxepine
Loxepine Brand names, Loxepine Analogs
Loxepine Brand Names Mixture
- No information avaliable
Loxepine Chemical_Formula
C18H18ClN3O
Loxepine RX_link
http://www.rxlist.com/cgi/generic2/loxapineoc.htm
Loxepine fda sheet
Loxepine msds (material safety sheet)
Loxepine Synthesis Reference
Neth. pat. Appl. 6,406,089 corresp to Schmutz et al., U.S. pat. 3,546,226 (1964, 1970 both to Wander)
Loxepine Molecular Weight
327.808 g/mol
Loxepine Melting Point
109-110 oC
Loxepine H2O Solubility
No information avaliable
Loxepine State
Solid
Loxepine LogP
3.162
Loxepine Dosage Forms
Tablet; Capsule; Oral solution; IV solution; IM solution
Loxepine Indication
For the management of the manifestations of psychotic disorders
Loxepine Pharmacology
Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established.
Loxepine Absorption
Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers
Loxepine side effects and Toxicity
LD50=65 mg/kg (Orally in mice)
Loxepine Patient Information
Loxepine Organisms Affected
Humans and other mammals
