Loxapine Succinate
Brand names,
Loxapine Succinate
Analogs
Loxapine Succinate
Brand Names Mixture
Loxapine Succinate
Chemical_Formula
C18H18ClN3O
Loxapine Succinate
RX_link
http://www.rxlist.com/cgi/generic2/loxapineoc.htm
Loxapine Succinate
fda sheet
Loxapine Succinate
msds (material safety sheet)
Loxapine Succinate
Synthesis Reference
Neth. pat. Appl. 6,406,089 corresp to Schmutz et al., U.S. pat. 3,546,226 (1964, 1970 both to Wander)
Loxapine Succinate
Molecular Weight
327.808 g/mol
Loxapine Succinate
Melting Point
109-110 oC
Loxapine Succinate
H2O Solubility
No information avaliable
Loxapine Succinate
State
Solid
Loxapine Succinate
LogP
3.162
Loxapine Succinate
Dosage Forms
Tablet; Capsule; Oral solution; IV solution; IM solution
Loxapine Succinate
Indication
For the management of the manifestations of psychotic disorders
Loxapine Succinate
Pharmacology
Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established.
Loxapine Succinate
Absorption
Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers
Loxapine Succinate
side effects and Toxicity
LD50=65 mg/kg (Orally in mice)
Loxapine Succinate
Patient Information
Loxapine Succinate
Organisms Affected
Humans and other mammals