Lossapina [Dcit]

Lossapina [Dcit] Brand names, Lossapina [Dcit] Analogs

Lossapina [Dcit] Brand Names Mixture

No information avaliable

Lossapina [Dcit] Chemical_Formula

C₁₈H₁₈ClN₃O

Lossapina [Dcit] RX_link

http://www.rxlist.com/cgi/generic2/loxapineoc.htm

Lossapina [Dcit] fda sheet

Lossapina [Dcit] msds (material safety sheet)

Lossapina [Dcit] Synthesis Reference

Neth. pat. Appl. 6,406,089 corresp to Schmutz et al., U.S. pat. 3,546,226 (1964, 1970 both to Wander)

Lossapina [Dcit] Molecular Weight

327.808 g/mol

Lossapina [Dcit] Melting Point

109-110 ^oC

Lossapina [Dcit] H₂O Solubility

No information avaliable

Lossapina [Dcit] State

Solid

Lossapina [Dcit] LogP

3.162

Lossapina [Dcit] Dosage Forms

Tablet; Capsule; Oral solution; IV solution; IM solution

Lossapina [Dcit] Indication

For the management of the manifestations of psychotic disorders

Lossapina [Dcit] Pharmacology

Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established.

Lossapina [Dcit] Absorption

Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers

Lossapina [Dcit] side effects and Toxicity

LD₅₀=65 mg/kg (Orally in mice)

Lossapina [Dcit] Patient Information

Lossapina [Dcit] Organisms Affected

Humans and other mammals