Hydrofluoride 3170
Brand names,
Hydrofluoride 3170
Analogs
Hydrofluoride 3170
Brand Names Mixture
Hydrofluoride 3170
Chemical_Formula
C18H18ClN3O
Hydrofluoride 3170
RX_link
http://www.rxlist.com/cgi/generic2/loxapineoc.htm
Hydrofluoride 3170
fda sheet
Hydrofluoride 3170
msds (material safety sheet)
Hydrofluoride 3170
Synthesis Reference
Neth. pat. Appl. 6,406,089 corresp to Schmutz et al., U.S. pat. 3,546,226 (1964, 1970 both to Wander)
Hydrofluoride 3170
Molecular Weight
327.808 g/mol
Hydrofluoride 3170
Melting Point
109-110 oC
Hydrofluoride 3170
H2O Solubility
No information avaliable
Hydrofluoride 3170
State
Solid
Hydrofluoride 3170
LogP
3.162
Hydrofluoride 3170
Dosage Forms
Tablet; Capsule; Oral solution; IV solution; IM solution
Hydrofluoride 3170
Indication
For the management of the manifestations of psychotic disorders
Hydrofluoride 3170
Pharmacology
Loxapine, a dibenzoxazepine compound, represents a subclass of tricyclic antipsychotic agents, chemically distinct from the thioxanthenes, butyrophenones, and phenothiazines. Pharmacologically, Loxapine is a tranquilizer for which the exact mode of action has not been established.
Hydrofluoride 3170
Absorption
Systemic bioavailability of the parent drug was only about one third that after an equivalent intramuscular dose (25 mg base) in male volunteers
Hydrofluoride 3170
side effects and Toxicity
LD50=65 mg/kg (Orally in mice)
Hydrofluoride 3170
Patient Information
Hydrofluoride 3170
Organisms Affected
Humans and other mammals