Limbitrol Ds
Brand names,
Limbitrol Ds
Analogs
Limbitrol Ds
Brand Names Mixture
- Apo-Chlorax Cap (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
- Corium Cap (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
- Librax (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
- Pro Chlorax (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
Limbitrol Ds
Chemical_Formula
C16H14ClN3O
Limbitrol Ds
RX_link
http://www.rxlist.com/cgi/generic/chlordia.htm
Limbitrol Ds
fda sheet
Limbitrol Ds
msds (material safety sheet)
Limbitrol Ds
Synthesis Reference
No information avaliable
Limbitrol Ds
Molecular Weight
299.755 g/mol
Limbitrol Ds
Melting Point
236.2 oC
Limbitrol Ds
H2O Solubility
2000 mg/L
Limbitrol Ds
State
Solid
Limbitrol Ds
LogP
2.853
Limbitrol Ds
Dosage Forms
Capsule (5 mg, 10 mg or 25 mg)
Limbitrol Ds
Indication
For the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.
Limbitrol Ds
Pharmacology
Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The precise mechanism of action is not known. The drug blocks EEG arousal from stimulation of the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals.
Limbitrol Ds
Absorption
No information avaliable
Limbitrol Ds
side effects and Toxicity
LD50=537 mg/kg (Orally in rats). Signs of overdose include respiratory depression, muscle weakness, somnolence (general depressed activity).
Limbitrol Ds
Patient Information
Limbitrol Ds
Organisms Affected
Humans and other mammals