Chlordiazepoxide Base
Brand names,
Chlordiazepoxide Base
Analogs
Chlordiazepoxide Base
Brand Names Mixture
- Apo-Chlorax Cap (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
- Corium Cap (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
- Librax (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
- Pro Chlorax (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
Chlordiazepoxide Base
Chemical_Formula
C16H14ClN3O
Chlordiazepoxide Base
RX_link
http://www.rxlist.com/cgi/generic/chlordia.htm
Chlordiazepoxide Base
fda sheet
Chlordiazepoxide Base
msds (material safety sheet)
Chlordiazepoxide Base
Synthesis Reference
No information avaliable
Chlordiazepoxide Base
Molecular Weight
299.755 g/mol
Chlordiazepoxide Base
Melting Point
236.2 oC
Chlordiazepoxide Base
H2O Solubility
2000 mg/L
Chlordiazepoxide Base
State
Solid
Chlordiazepoxide Base
LogP
2.853
Chlordiazepoxide Base
Dosage Forms
Capsule (5 mg, 10 mg or 25 mg)
Chlordiazepoxide Base
Indication
For the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.
Chlordiazepoxide Base
Pharmacology
Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The precise mechanism of action is not known. The drug blocks EEG arousal from stimulation of the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals.
Chlordiazepoxide Base
Absorption
No information avaliable
Chlordiazepoxide Base
side effects and Toxicity
LD50=537 mg/kg (Orally in rats). Signs of overdose include respiratory depression, muscle weakness, somnolence (general depressed activity).
Chlordiazepoxide Base
Patient Information
Chlordiazepoxide Base
Organisms Affected
Humans and other mammals