Abboxide
Brand names,
Abboxide
Analogs
Abboxide
Brand Names Mixture
- Apo-Chlorax Cap (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
- Corium Cap (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
- Librax (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
- Pro Chlorax (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
Abboxide
Chemical_Formula
C16H14ClN3O
Abboxide
RX_link
http://www.rxlist.com/cgi/generic/chlordia.htm
Abboxide
fda sheet
Abboxide
msds (material safety sheet)
Abboxide
Synthesis Reference
No information avaliable
Abboxide
Molecular Weight
299.755 g/mol
Abboxide
Melting Point
236.2 oC
Abboxide
H2O Solubility
2000 mg/L
Abboxide
State
Solid
Abboxide
LogP
2.853
Abboxide
Dosage Forms
Capsule (5 mg, 10 mg or 25 mg)
Abboxide
Indication
For the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.
Abboxide
Pharmacology
Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The precise mechanism of action is not known. The drug blocks EEG arousal from stimulation of the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals.
Abboxide
Absorption
No information avaliable
Abboxide
side effects and Toxicity
LD50=537 mg/kg (Orally in rats). Signs of overdose include respiratory depression, muscle weakness, somnolence (general depressed activity).
Abboxide
Patient Information
Abboxide
Organisms Affected
Humans and other mammals