Chlordiazepoxide Hcl
Brand names,
Chlordiazepoxide Hcl
Analogs
Chlordiazepoxide Hcl
Brand Names Mixture
- Apo-Chlorax Cap (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
- Corium Cap (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
- Librax (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
- Pro Chlorax (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
Chlordiazepoxide Hcl
Chemical_Formula
C16H14ClN3O
Chlordiazepoxide Hcl
RX_link
http://www.rxlist.com/cgi/generic/chlordia.htm
Chlordiazepoxide Hcl
fda sheet
Chlordiazepoxide Hcl
msds (material safety sheet)
Chlordiazepoxide Hcl
Synthesis Reference
No information avaliable
Chlordiazepoxide Hcl
Molecular Weight
299.755 g/mol
Chlordiazepoxide Hcl
Melting Point
236.2 oC
Chlordiazepoxide Hcl
H2O Solubility
2000 mg/L
Chlordiazepoxide Hcl
State
Solid
Chlordiazepoxide Hcl
LogP
2.853
Chlordiazepoxide Hcl
Dosage Forms
Capsule (5 mg, 10 mg or 25 mg)
Chlordiazepoxide Hcl
Indication
For the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.
Chlordiazepoxide Hcl
Pharmacology
Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The precise mechanism of action is not known. The drug blocks EEG arousal from stimulation of the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals.
Chlordiazepoxide Hcl
Absorption
No information avaliable
Chlordiazepoxide Hcl
side effects and Toxicity
LD50=537 mg/kg (Orally in rats). Signs of overdose include respiratory depression, muscle weakness, somnolence (general depressed activity).
Chlordiazepoxide Hcl
Patient Information
Chlordiazepoxide Hcl
Organisms Affected
Humans and other mammals