Kalmocaps
Brand names,
Kalmocaps
Analogs
Kalmocaps
Brand Names Mixture
- Apo-Chlorax Cap (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
- Corium Cap (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
- Librax (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
- Pro Chlorax (Chlordiazepoxide Hydrochloride + Clidinium Bromide)
Kalmocaps
Chemical_Formula
C16H14ClN3O
Kalmocaps
RX_link
http://www.rxlist.com/cgi/generic/chlordia.htm
Kalmocaps
fda sheet
Kalmocaps
msds (material safety sheet)
Kalmocaps
Synthesis Reference
No information avaliable
Kalmocaps
Molecular Weight
299.755 g/mol
Kalmocaps
Melting Point
236.2 oC
Kalmocaps
H2O Solubility
2000 mg/L
Kalmocaps
State
Solid
Kalmocaps
LogP
2.853
Kalmocaps
Dosage Forms
Capsule (5 mg, 10 mg or 25 mg)
Kalmocaps
Indication
For the management of anxiety disorders or for the short-term relief of symptoms of anxiety, withdrawal symptoms of acute alcoholism, and preoperative apprehension and anxiety.
Kalmocaps
Pharmacology
Chlordiazepoxide has antianxiety, sedative, appetite-stimulating and weak analgesic actions. The precise mechanism of action is not known. The drug blocks EEG arousal from stimulation of the brain stem reticular formation. The drug has been studied extensively in many species of animals and these studies are suggestive of action on the limbic system of the brain, which recent evidence indicates is involved in emotional responses. Hostile monkeys were made tame by oral drug doses which did not cause sedation. Chlordiazepoxide revealed a "taming" action with the elimination of fear and aggression. The taming effect of chlordiazepoxide was further demonstrated in rats made vicious by lesions in the septal area of the brain. The drug dosage which effectively blocked the vicious reaction was well below the dose which caused sedation in these animals.
Kalmocaps
Absorption
No information avaliable
Kalmocaps
side effects and Toxicity
LD50=537 mg/kg (Orally in rats). Signs of overdose include respiratory depression, muscle weakness, somnolence (general depressed activity).
Kalmocaps
Patient Information
Kalmocaps
Organisms Affected
Humans and other mammals