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Brand names,
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Analogs
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Brand Names Mixture
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Chemical_Formula
C26H29FN2O2
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RX_link
http://www.rxlist.com/cgi/generic2/livostin.htm
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fda sheet
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msds (material safety sheet)
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Synthesis Reference
No information avaliable
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Molecular Weight
420.519 g/mol
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Melting Point
No information avaliable
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H2O Solubility
>0.5 mg/mL
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State
Solid
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LogP
6.3
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Dosage Forms
Drops; Spray
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Indication
As an ophthalmic for the temporary relief of the signs and symptoms of seasonal allergic conjunctivitis. Also used as a nasal spray for allergic rhinitis.
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Pharmacology
Levocabastine is a selective histamine H1-receptor antagonist exerting inhibitory effects on the release of chemical mediators from mast cells and on the chemotaxis of polymorphonuclear leukocytes and eosinophils. Both histamine and antigens induced conjunctivitis can be inhibited by levocabastine. Levocabastine can also reduce symptoms of allergic rhinitis by preventing an increase in vascular permeability of nasal mucosa.
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Absorption
After instillation in the eye, levocabastine is systemically absorbed, albeit at low levels.
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side effects and Toxicity
Adverse effects include visual disturbances, dry mouth, cough, nausea, eyelid edema and lacrimation.
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Patient Information
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Organisms Affected
Humans and other mammals