Evalose
Brand names,
Evalose
Analogs
Evalose
Brand Names Mixture
Evalose
Chemical_Formula
C26H29FN2O2
Evalose
RX_link
http://www.rxlist.com/cgi/generic2/livostin.htm
Evalose
fda sheet
Evalose
msds (material safety sheet)
Evalose
Synthesis Reference
No information avaliable
Evalose
Molecular Weight
420.519 g/mol
Evalose
Melting Point
No information avaliable
Evalose
H2O Solubility
>0.5 mg/mL
Evalose
State
Solid
Evalose
LogP
6.3
Evalose
Dosage Forms
Drops; Spray
Evalose
Indication
As an ophthalmic for the temporary relief of the signs and symptoms of seasonal allergic conjunctivitis. Also used as a nasal spray for allergic rhinitis.
Evalose
Pharmacology
Levocabastine is a selective histamine H1-receptor antagonist exerting inhibitory effects on the release of chemical mediators from mast cells and on the chemotaxis of polymorphonuclear leukocytes and eosinophils. Both histamine and antigens induced conjunctivitis can be inhibited by levocabastine. Levocabastine can also reduce symptoms of allergic rhinitis by preventing an increase in vascular permeability of nasal mucosa.
Evalose
Absorption
After instillation in the eye, levocabastine is systemically absorbed, albeit at low levels.
Evalose
side effects and Toxicity
Adverse effects include visual disturbances, dry mouth, cough, nausea, eyelid edema and lacrimation.
Evalose
Patient Information
Evalose
Organisms Affected
Humans and other mammals