Constilac
Brand names,
Constilac
Analogs
Constilac
Brand Names Mixture
Constilac
Chemical_Formula
C26H29FN2O2
Constilac
RX_link
http://www.rxlist.com/cgi/generic2/livostin.htm
Constilac
fda sheet
Constilac
msds (material safety sheet)
Constilac
Synthesis Reference
No information avaliable
Constilac
Molecular Weight
420.519 g/mol
Constilac
Melting Point
No information avaliable
Constilac
H2O Solubility
>0.5 mg/mL
Constilac
State
Solid
Constilac
LogP
6.3
Constilac
Dosage Forms
Drops; Spray
Constilac
Indication
As an ophthalmic for the temporary relief of the signs and symptoms of seasonal allergic conjunctivitis. Also used as a nasal spray for allergic rhinitis.
Constilac
Pharmacology
Levocabastine is a selective histamine H1-receptor antagonist exerting inhibitory effects on the release of chemical mediators from mast cells and on the chemotaxis of polymorphonuclear leukocytes and eosinophils. Both histamine and antigens induced conjunctivitis can be inhibited by levocabastine. Levocabastine can also reduce symptoms of allergic rhinitis by preventing an increase in vascular permeability of nasal mucosa.
Constilac
Absorption
After instillation in the eye, levocabastine is systemically absorbed, albeit at low levels.
Constilac
side effects and Toxicity
Adverse effects include visual disturbances, dry mouth, cough, nausea, eyelid edema and lacrimation.
Constilac
Patient Information
Constilac
Organisms Affected
Humans and other mammals