Constulose
Brand names,
Constulose
Analogs
Constulose
Brand Names Mixture
Constulose
Chemical_Formula
C26H29FN2O2
Constulose
RX_link
http://www.rxlist.com/cgi/generic2/livostin.htm
Constulose
fda sheet
Constulose
msds (material safety sheet)
Constulose
Synthesis Reference
No information avaliable
Constulose
Molecular Weight
420.519 g/mol
Constulose
Melting Point
No information avaliable
Constulose
H2O Solubility
>0.5 mg/mL
Constulose
State
Solid
Constulose
LogP
6.3
Constulose
Dosage Forms
Drops; Spray
Constulose
Indication
As an ophthalmic for the temporary relief of the signs and symptoms of seasonal allergic conjunctivitis. Also used as a nasal spray for allergic rhinitis.
Constulose
Pharmacology
Levocabastine is a selective histamine H1-receptor antagonist exerting inhibitory effects on the release of chemical mediators from mast cells and on the chemotaxis of polymorphonuclear leukocytes and eosinophils. Both histamine and antigens induced conjunctivitis can be inhibited by levocabastine. Levocabastine can also reduce symptoms of allergic rhinitis by preventing an increase in vascular permeability of nasal mucosa.
Constulose
Absorption
After instillation in the eye, levocabastine is systemically absorbed, albeit at low levels.
Constulose
side effects and Toxicity
Adverse effects include visual disturbances, dry mouth, cough, nausea, eyelid edema and lacrimation.
Constulose
Patient Information
Constulose
Organisms Affected
Humans and other mammals