Kinestase
Kinestase Brand names, Kinestase Analogs
Kinestase Brand Names Mixture
- No information avaliable
Kinestase Chemical_Formula
C23H29ClFN3O4
Kinestase RX_link
http://www.rxlist.com/cgi/generic/cisap.htm
Kinestase fda sheet
Kinestase msds (material safety sheet)
Kinestase Synthesis Reference
No information avaliable
Kinestase Molecular Weight
465.945 g/mol
Kinestase Melting Point
110 oC
Kinestase H2O Solubility
2.71 mg/L
Kinestase State
Solid
Kinestase LogP
3.802
Kinestase Dosage Forms
Suspension; Tablet
Kinestase Indication
For the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease.
Kinestase Pharmacology
Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. Cisapride stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Cisapride increases the tone and amplitude of gastric (especially antral) contractions, relaxes the pyloric sphincter and the duodenal bulb, and increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit. It increases the resting tone of the lower esophageal sphincter. It has little, if any, effect on the motility of the colon or gallbladder. Cisapride does not induce muscarinic or nicotinic receptor stimulation, nor does it inhibit acetylcholinesterase activity.
Kinestase Absorption
Cisapride is rapidly absorbed after oral administration, with an absolute bioavailability of 35-40%.
Kinestase side effects and Toxicity
No information avaliable
Kinestase Patient Information
No information avaliable
Kinestase Organisms Affected
Humans and other mammals
