Syspride
Syspride Brand names, Syspride Analogs
Syspride Brand Names Mixture
- No information avaliable
Syspride Chemical_Formula
C23H29ClFN3O4
Syspride RX_link
http://www.rxlist.com/cgi/generic/cisap.htm
Syspride fda sheet
Syspride msds (material safety sheet)
Syspride Synthesis Reference
No information avaliable
Syspride Molecular Weight
465.945 g/mol
Syspride Melting Point
110 oC
Syspride H2O Solubility
2.71 mg/L
Syspride State
Solid
Syspride LogP
3.802
Syspride Dosage Forms
Suspension; Tablet
Syspride Indication
For the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease.
Syspride Pharmacology
Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. Cisapride stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Cisapride increases the tone and amplitude of gastric (especially antral) contractions, relaxes the pyloric sphincter and the duodenal bulb, and increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit. It increases the resting tone of the lower esophageal sphincter. It has little, if any, effect on the motility of the colon or gallbladder. Cisapride does not induce muscarinic or nicotinic receptor stimulation, nor does it inhibit acetylcholinesterase activity.
Syspride Absorption
Cisapride is rapidly absorbed after oral administration, with an absolute bioavailability of 35-40%.
Syspride side effects and Toxicity
No information avaliable
Syspride Patient Information
No information avaliable
Syspride Organisms Affected
Humans and other mammals
