Prepulsid
Prepulsid Brand names, Prepulsid Analogs
Prepulsid Brand Names Mixture
- No information avaliable
Prepulsid Chemical_Formula
C23H29ClFN3O4
Prepulsid RX_link
http://www.rxlist.com/cgi/generic/cisap.htm
Prepulsid fda sheet
Prepulsid msds (material safety sheet)
Prepulsid Synthesis Reference
No information avaliable
Prepulsid Molecular Weight
465.945 g/mol
Prepulsid Melting Point
110 oC
Prepulsid H2O Solubility
2.71 mg/L
Prepulsid State
Solid
Prepulsid LogP
3.802
Prepulsid Dosage Forms
Suspension; Tablet
Prepulsid Indication
For the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease.
Prepulsid Pharmacology
Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. Cisapride stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Cisapride increases the tone and amplitude of gastric (especially antral) contractions, relaxes the pyloric sphincter and the duodenal bulb, and increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit. It increases the resting tone of the lower esophageal sphincter. It has little, if any, effect on the motility of the colon or gallbladder. Cisapride does not induce muscarinic or nicotinic receptor stimulation, nor does it inhibit acetylcholinesterase activity.
Prepulsid Absorption
Cisapride is rapidly absorbed after oral administration, with an absolute bioavailability of 35-40%.
Prepulsid side effects and Toxicity
No information avaliable
Prepulsid Patient Information
No information avaliable
Prepulsid Organisms Affected
Humans and other mammals
