Propulsin
Propulsin Brand names, Propulsin Analogs
Propulsin Brand Names Mixture
- No information avaliable
Propulsin Chemical_Formula
C23H29ClFN3O4
Propulsin RX_link
http://www.rxlist.com/cgi/generic/cisap.htm
Propulsin fda sheet
Propulsin msds (material safety sheet)
Propulsin Synthesis Reference
No information avaliable
Propulsin Molecular Weight
465.945 g/mol
Propulsin Melting Point
110 oC
Propulsin H2O Solubility
2.71 mg/L
Propulsin State
Solid
Propulsin LogP
3.802
Propulsin Dosage Forms
Suspension; Tablet
Propulsin Indication
For the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease.
Propulsin Pharmacology
Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. Cisapride stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Cisapride increases the tone and amplitude of gastric (especially antral) contractions, relaxes the pyloric sphincter and the duodenal bulb, and increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit. It increases the resting tone of the lower esophageal sphincter. It has little, if any, effect on the motility of the colon or gallbladder. Cisapride does not induce muscarinic or nicotinic receptor stimulation, nor does it inhibit acetylcholinesterase activity.
Propulsin Absorption
Cisapride is rapidly absorbed after oral administration, with an absolute bioavailability of 35-40%.
Propulsin side effects and Toxicity
No information avaliable
Propulsin Patient Information
No information avaliable
Propulsin Organisms Affected
Humans and other mammals
