Propulsin

• Gastrointestinal Agents
• Anti-ulcer Agents
• Prokinetic Agents
• Serotonin Agonists
• ATC:A03FA02

• Acenalin
• Alimix
• Cipril
• Enteropride
• Kinestase
• Prepulsid
• Pridesia
• Propulsid
• Propulsid Quicksolv
• Propulsin
• Risamal
• Syspride

• No information avaliable

C₂₃H₂₉ClFN₃O₄

http://www.rxlist.com/cgi/generic/cisap.htm

Propulsin MSDS

No information avaliable

465.945 g/mol

110 ^oC

2.71 mg/L

Solid

3.802

Suspension; Tablet

For the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease.

Cisapride is a parasympathomimetic which acts as a serotonin 5-HT₄ agonist. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. Cisapride stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Cisapride increases the tone and amplitude of gastric (especially antral) contractions, relaxes the pyloric sphincter and the duodenal bulb, and increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit. It increases the resting tone of the lower esophageal sphincter. It has little, if any, effect on the motility of the colon or gallbladder. Cisapride does not induce muscarinic or nicotinic receptor stimulation, nor does it inhibit acetylcholinesterase activity.

Cisapride is rapidly absorbed after oral administration, with an absolute bioavailability of 35-40%.

No information avaliable

No information avaliable

Humans and other mammals