Risamal
Risamal Brand names, Risamal Analogs
Risamal Brand Names Mixture
- No information avaliable
Risamal Chemical_Formula
C23H29ClFN3O4
Risamal RX_link
http://www.rxlist.com/cgi/generic/cisap.htm
Risamal fda sheet
Risamal msds (material safety sheet)
Risamal Synthesis Reference
No information avaliable
Risamal Molecular Weight
465.945 g/mol
Risamal Melting Point
110 oC
Risamal H2O Solubility
2.71 mg/L
Risamal State
Solid
Risamal LogP
3.802
Risamal Dosage Forms
Suspension; Tablet
Risamal Indication
For the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease.
Risamal Pharmacology
Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. Cisapride stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Cisapride increases the tone and amplitude of gastric (especially antral) contractions, relaxes the pyloric sphincter and the duodenal bulb, and increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit. It increases the resting tone of the lower esophageal sphincter. It has little, if any, effect on the motility of the colon or gallbladder. Cisapride does not induce muscarinic or nicotinic receptor stimulation, nor does it inhibit acetylcholinesterase activity.
Risamal Absorption
Cisapride is rapidly absorbed after oral administration, with an absolute bioavailability of 35-40%.
Risamal side effects and Toxicity
No information avaliable
Risamal Patient Information
No information avaliable
Risamal Organisms Affected
Humans and other mammals
