Propulsid
Propulsid Brand names, Propulsid Analogs
Propulsid Brand Names Mixture
- No information avaliable
Propulsid Chemical_Formula
C23H29ClFN3O4
Propulsid RX_link
http://www.rxlist.com/cgi/generic/cisap.htm
Propulsid fda sheet
Propulsid msds (material safety sheet)
Propulsid Synthesis Reference
No information avaliable
Propulsid Molecular Weight
465.945 g/mol
Propulsid Melting Point
110 oC
Propulsid H2O Solubility
2.71 mg/L
Propulsid State
Solid
Propulsid LogP
3.802
Propulsid Dosage Forms
Suspension; Tablet
Propulsid Indication
For the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease.
Propulsid Pharmacology
Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. Cisapride stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Cisapride increases the tone and amplitude of gastric (especially antral) contractions, relaxes the pyloric sphincter and the duodenal bulb, and increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit. It increases the resting tone of the lower esophageal sphincter. It has little, if any, effect on the motility of the colon or gallbladder. Cisapride does not induce muscarinic or nicotinic receptor stimulation, nor does it inhibit acetylcholinesterase activity.
Propulsid Absorption
Cisapride is rapidly absorbed after oral administration, with an absolute bioavailability of 35-40%.
Propulsid side effects and Toxicity
No information avaliable
Propulsid Patient Information
No information avaliable
Propulsid Organisms Affected
Humans and other mammals
