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FUDR Brand names, FUDR Analogs

FUDR Brand Names Mixture

  • No information avaliable

FUDR Chemical_Formula


FUDR RX_link


FUDR fda sheet


FUDR msds (material safety sheet)


FUDR Synthesis Reference

No information avaliable

FUDR Molecular Weight

246.193 g/mol

FUDR Melting Point

150.5 oC

FUDR H2O Solubility

1.19E+004 mg/L

FUDR State




FUDR Dosage Forms

Powder for solution (500mg vial)

FUDR Indication

For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.

FUDR Pharmacology

Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.

FUDR Absorption

No information avaliable

FUDR side effects and Toxicity

Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).

FUDR Patient Information

FUDR Organisms Affected

Humans and other mammals