FUDR
FUDR Brand names, FUDR Analogs
FUDR Brand Names Mixture
- No information avaliable
FUDR Chemical_Formula
C9H11FN2O5
FUDR RX_link
http://www.rxlist.com/cgi/generic2/floxuridine.htm
FUDR fda sheet
FUDR msds (material safety sheet)
FUDR Synthesis Reference
No information avaliable
FUDR Molecular Weight
246.193 g/mol
FUDR Melting Point
150.5 oC
FUDR H2O Solubility
1.19E+004 mg/L
FUDR State
Solid
FUDR LogP
-1.249
FUDR Dosage Forms
Powder for solution (500mg vial)
FUDR Indication
For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.
FUDR Pharmacology
Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.
FUDR Absorption
No information avaliable
FUDR side effects and Toxicity
Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).
FUDR Patient Information
FUDR Organisms Affected
Humans and other mammals
