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Fluorodeoxyuridine Brand names, Fluorodeoxyuridine Analogs

Fluorodeoxyuridine Brand Names Mixture

  • No information avaliable

Fluorodeoxyuridine Chemical_Formula


Fluorodeoxyuridine RX_link


Fluorodeoxyuridine fda sheet


Fluorodeoxyuridine msds (material safety sheet)

Fluorodeoxyuridine MSDS

Fluorodeoxyuridine Synthesis Reference

No information avaliable

Fluorodeoxyuridine Molecular Weight

246.193 g/mol

Fluorodeoxyuridine Melting Point

150.5 oC

Fluorodeoxyuridine H2O Solubility

1.19E+004 mg/L

Fluorodeoxyuridine State


Fluorodeoxyuridine LogP


Fluorodeoxyuridine Dosage Forms

Powder for solution (500mg vial)

Fluorodeoxyuridine Indication

For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.

Fluorodeoxyuridine Pharmacology

Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.

Fluorodeoxyuridine Absorption

No information avaliable

Fluorodeoxyuridine side effects and Toxicity

Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).

Fluorodeoxyuridine Patient Information

Fluorodeoxyuridine Organisms Affected

Humans and other mammals