Floxuridin
Floxuridin Brand names, Floxuridin Analogs
Floxuridin Brand Names Mixture
- No information avaliable
Floxuridin Chemical_Formula
C9H11FN2O5
Floxuridin RX_link
http://www.rxlist.com/cgi/generic2/floxuridine.htm
Floxuridin fda sheet
Floxuridin msds (material safety sheet)
Floxuridin Synthesis Reference
No information avaliable
Floxuridin Molecular Weight
246.193 g/mol
Floxuridin Melting Point
150.5 oC
Floxuridin H2O Solubility
1.19E+004 mg/L
Floxuridin State
Solid
Floxuridin LogP
-1.249
Floxuridin Dosage Forms
Powder for solution (500mg vial)
Floxuridin Indication
For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.
Floxuridin Pharmacology
Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.
Floxuridin Absorption
No information avaliable
Floxuridin side effects and Toxicity
Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).
Floxuridin Patient Information
Floxuridin Organisms Affected
Humans and other mammals
