FDUR
FDUR Brand names, FDUR Analogs
FDUR Brand Names Mixture
- No information avaliable
FDUR Chemical_Formula
C9H11FN2O5
FDUR RX_link
http://www.rxlist.com/cgi/generic2/floxuridine.htm
FDUR fda sheet
FDUR msds (material safety sheet)
FDUR Synthesis Reference
No information avaliable
FDUR Molecular Weight
246.193 g/mol
FDUR Melting Point
150.5 oC
FDUR H2O Solubility
1.19E+004 mg/L
FDUR State
Solid
FDUR LogP
-1.249
FDUR Dosage Forms
Powder for solution (500mg vial)
FDUR Indication
For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.
FDUR Pharmacology
Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.
FDUR Absorption
No information avaliable
FDUR side effects and Toxicity
Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).
FDUR Patient Information
FDUR Organisms Affected
Humans and other mammals
