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FDUR Brand names, FDUR Analogs

FDUR Brand Names Mixture

  • No information avaliable

FDUR Chemical_Formula


FDUR RX_link


FDUR fda sheet


FDUR msds (material safety sheet)


FDUR Synthesis Reference

No information avaliable

FDUR Molecular Weight

246.193 g/mol

FDUR Melting Point

150.5 oC

FDUR H2O Solubility

1.19E+004 mg/L

FDUR State




FDUR Dosage Forms

Powder for solution (500mg vial)

FDUR Indication

For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.

FDUR Pharmacology

Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.

FDUR Absorption

No information avaliable

FDUR side effects and Toxicity

Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).

FDUR Patient Information

FDUR Organisms Affected

Humans and other mammals