Fluoruridine Deoxyribose

Fluoruridine Deoxyribose Brand names, Fluoruridine Deoxyribose Analogs

Fluoruridine Deoxyribose Brand Names Mixture

No information avaliable

Fluoruridine Deoxyribose Chemical_Formula

C₉H₁₁FN₂O₅

Fluoruridine Deoxyribose RX_link

http://www.rxlist.com/cgi/generic2/floxuridine.htm

Fluoruridine Deoxyribose fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=floxuridine%20(intraarterial)

Fluoruridine Deoxyribose msds (material safety sheet)

Fluoruridine_Deoxyribose MSDS

Fluoruridine Deoxyribose Synthesis Reference

No information avaliable

Fluoruridine Deoxyribose Molecular Weight

246.193 g/mol

Fluoruridine Deoxyribose Melting Point

150.5 ^oC

Fluoruridine Deoxyribose H₂O Solubility

1.19E+004 mg/L

Fluoruridine Deoxyribose State

Solid

Fluoruridine Deoxyribose LogP

-1.249

Fluoruridine Deoxyribose Dosage Forms

Powder for solution (500mg vial)

Fluoruridine Deoxyribose Indication

For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.

Fluoruridine Deoxyribose Pharmacology

Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.

Fluoruridine Deoxyribose Absorption