Floxiridina [Inn-Spanish] en es it fr

Floxiridina [Inn-Spanish] Brand names, Floxiridina [Inn-Spanish] Analogs

Floxiridina [Inn-Spanish] Brand Names Mixture

  • No information avaliable

Floxiridina [Inn-Spanish] Chemical_Formula


Floxiridina [Inn-Spanish] RX_link


Floxiridina [Inn-Spanish] fda sheet


Floxiridina [Inn-Spanish] msds (material safety sheet)

Floxiridina_[Inn-Spanish] MSDS

Floxiridina [Inn-Spanish] Synthesis Reference

No information avaliable

Floxiridina [Inn-Spanish] Molecular Weight

246.193 g/mol

Floxiridina [Inn-Spanish] Melting Point

150.5 oC

Floxiridina [Inn-Spanish] H2O Solubility

1.19E+004 mg/L

Floxiridina [Inn-Spanish] State


Floxiridina [Inn-Spanish] LogP


Floxiridina [Inn-Spanish] Dosage Forms

Powder for solution (500mg vial)

Floxiridina [Inn-Spanish] Indication

For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.

Floxiridina [Inn-Spanish] Pharmacology

Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.

Floxiridina [Inn-Spanish] Absorption

No information avaliable

Floxiridina [Inn-Spanish] side effects and Toxicity

Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).

Floxiridina [Inn-Spanish] Patient Information

Floxiridina [Inn-Spanish] Organisms Affected

Humans and other mammals