Fdurd
Fdurd Brand names, Fdurd Analogs
Fdurd Brand Names Mixture
- No information avaliable
Fdurd Chemical_Formula
C9H11FN2O5
Fdurd RX_link
http://www.rxlist.com/cgi/generic2/floxuridine.htm
Fdurd fda sheet
Fdurd msds (material safety sheet)
Fdurd Synthesis Reference
No information avaliable
Fdurd Molecular Weight
246.193 g/mol
Fdurd Melting Point
150.5 oC
Fdurd H2O Solubility
1.19E+004 mg/L
Fdurd State
Solid
Fdurd LogP
-1.249
Fdurd Dosage Forms
Powder for solution (500mg vial)
Fdurd Indication
For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.
Fdurd Pharmacology
Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.
Fdurd Absorption
No information avaliable
Fdurd side effects and Toxicity
Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).
Fdurd Patient Information
Fdurd Organisms Affected
Humans and other mammals
