5 Fluorodeoxyuridine

5 Fluorodeoxyuridine Brand names, 5 Fluorodeoxyuridine Analogs

5 Fluorodeoxyuridine Brand Names Mixture

No information avaliable

5 Fluorodeoxyuridine Chemical_Formula

C₉H₁₁FN₂O₅

5 Fluorodeoxyuridine RX_link

http://www.rxlist.com/cgi/generic2/floxuridine.htm

5 Fluorodeoxyuridine fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=floxuridine%20(intraarterial)

5 Fluorodeoxyuridine msds (material safety sheet)

5_Fluorodeoxyuridine MSDS

5 Fluorodeoxyuridine Synthesis Reference

No information avaliable

5 Fluorodeoxyuridine Molecular Weight

246.193 g/mol

5 Fluorodeoxyuridine Melting Point

150.5 ^oC

5 Fluorodeoxyuridine H₂O Solubility

1.19E+004 mg/L

5 Fluorodeoxyuridine State

Solid

5 Fluorodeoxyuridine LogP

-1.249

5 Fluorodeoxyuridine Dosage Forms

Powder for solution (500mg vial)

5 Fluorodeoxyuridine Indication

For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.

5 Fluorodeoxyuridine Pharmacology

Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.

5 Fluorodeoxyuridine Absorption