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5fdu Brand names, 5fdu Analogs

5fdu Brand Names Mixture

  • No information avaliable

5fdu Chemical_Formula


5fdu RX_link


5fdu fda sheet


5fdu msds (material safety sheet)

5fdu MSDS

5fdu Synthesis Reference

No information avaliable

5fdu Molecular Weight

246.193 g/mol

5fdu Melting Point

150.5 oC

5fdu H2O Solubility

1.19E+004 mg/L

5fdu State


5fdu LogP


5fdu Dosage Forms

Powder for solution (500mg vial)

5fdu Indication

For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.

5fdu Pharmacology

Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.

5fdu Absorption

No information avaliable

5fdu side effects and Toxicity

Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).

5fdu Patient Information

5fdu Organisms Affected

Humans and other mammals