5fdu
5fdu Brand names, 5fdu Analogs
5fdu Brand Names Mixture
- No information avaliable
5fdu Chemical_Formula
C9H11FN2O5
5fdu RX_link
http://www.rxlist.com/cgi/generic2/floxuridine.htm
5fdu fda sheet
5fdu msds (material safety sheet)
5fdu Synthesis Reference
No information avaliable
5fdu Molecular Weight
246.193 g/mol
5fdu Melting Point
150.5 oC
5fdu H2O Solubility
1.19E+004 mg/L
5fdu State
Solid
5fdu LogP
-1.249
5fdu Dosage Forms
Powder for solution (500mg vial)
5fdu Indication
For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.
5fdu Pharmacology
Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.
5fdu Absorption
No information avaliable
5fdu side effects and Toxicity
Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).
5fdu Patient Information
5fdu Organisms Affected
Humans and other mammals
