Deoxyfluorouridine en es it fr

Deoxyfluorouridine Brand names, Deoxyfluorouridine Analogs

Deoxyfluorouridine Brand Names Mixture

  • No information avaliable

Deoxyfluorouridine Chemical_Formula


Deoxyfluorouridine RX_link

Deoxyfluorouridine fda sheet

Deoxyfluorouridine msds (material safety sheet)

Deoxyfluorouridine MSDS

Deoxyfluorouridine Synthesis Reference

No information avaliable

Deoxyfluorouridine Molecular Weight

246.193 g/mol

Deoxyfluorouridine Melting Point

150.5 oC

Deoxyfluorouridine H2O Solubility

1.19E+004 mg/L

Deoxyfluorouridine State


Deoxyfluorouridine LogP


Deoxyfluorouridine Dosage Forms

Powder for solution (500mg vial)

Deoxyfluorouridine Indication

For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.

Deoxyfluorouridine Pharmacology

Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.

Deoxyfluorouridine Absorption

No information avaliable

Deoxyfluorouridine side effects and Toxicity

Oral, rat LD50: 215 mg/kg. Signs of overdose include nausea, vomiting, diarrhea, gastrointestinal ulceration and bleeding, and bone marrow depression (including thrombocytopenia, leukopenia and agranulocytosis).

Deoxyfluorouridine Patient Information

Deoxyfluorouridine Organisms Affected

Humans and other mammals