Deoxyfluorouridine

Deoxyfluorouridine Brand names, Deoxyfluorouridine Analogs

Deoxyfluorouridine Brand Names Mixture

No information avaliable

Deoxyfluorouridine Chemical_Formula

C₉H₁₁FN₂O₅

Deoxyfluorouridine RX_link

http://www.rxlist.com/cgi/generic2/floxuridine.htm

Deoxyfluorouridine fda sheet

http://www.accessdata.fda.gov/scripts/cder/onctools/labels.cfm?GN=floxuridine%20(intraarterial)

Deoxyfluorouridine msds (material safety sheet)

Deoxyfluorouridine MSDS

Deoxyfluorouridine Synthesis Reference

No information avaliable

Deoxyfluorouridine Molecular Weight

246.193 g/mol

Deoxyfluorouridine Melting Point

150.5 ^oC

Deoxyfluorouridine H₂O Solubility

1.19E+004 mg/L

Deoxyfluorouridine State

Solid

Deoxyfluorouridine LogP

-1.249

Deoxyfluorouridine Dosage Forms

Powder for solution (500mg vial)

Deoxyfluorouridine Indication

For palliative management of gastrointestinal adenocarcinoma metastatic to the liver, when given by continuous regional intra-arterial infusion in carefully selected patients who are considered incurable by surgery or other means.

Deoxyfluorouridine Pharmacology

Floxuridine is a pyrimidine analog that acts as an inhibitor of the S-phase of cell division. This selectively kills rapidly dividing cells. Floxuridine is an anti-metabolite. Anti-metabolites masquerade as pyramidine-like molecules which prevents normal pyrimidines from being incorporated into DNA during the S phase of the cell cycle. Flurouracil (the end-product of catabolism of floxuridine) blacks an enzyme which converts cytosine nucleosides into the deoxy derivative. In addition, DNA synthesis is further inhibited because fluoruracil blocks the incorporation of the thymdine nucleotide into the DNA strand.

Deoxyfluorouridine Absorption