Cisapride
Cisapride Brand names, Cisapride Analogs
Cisapride Brand Names Mixture
- No information avaliable
Cisapride Chemical_Formula
C23H29ClFN3O4
Cisapride RX_link
http://www.rxlist.com/cgi/generic/cisap.htm
Cisapride fda sheet
Cisapride msds (material safety sheet)
Cisapride Synthesis Reference
No information avaliable
Cisapride Molecular Weight
465.945 g/mol
Cisapride Melting Point
110 oC
Cisapride H2O Solubility
2.71 mg/L
Cisapride State
Solid
Cisapride LogP
3.802
Cisapride Dosage Forms
Suspension; Tablet
Cisapride Indication
For the symptomatic treatment of adult patients with nocturnal heartburn due to gastroesophageal reflux disease.
Cisapride Pharmacology
Cisapride is a parasympathomimetic which acts as a serotonin 5-HT4 agonist. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous system. Cisapride stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. Cisapride increases the tone and amplitude of gastric (especially antral) contractions, relaxes the pyloric sphincter and the duodenal bulb, and increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transit. It increases the resting tone of the lower esophageal sphincter. It has little, if any, effect on the motility of the colon or gallbladder. Cisapride does not induce muscarinic or nicotinic receptor stimulation, nor does it inhibit acetylcholinesterase activity.
Cisapride Absorption
Cisapride is rapidly absorbed after oral administration, with an absolute bioavailability of 35-40%.
Cisapride side effects and Toxicity
No information avaliable
Cisapride Patient Information
No information avaliable
Cisapride Organisms Affected
Humans and other mammals
