PharmacyCodes



Tecto 10P en es it fr

Tecto 10P Brand names, Tecto 10P Analogs

Tecto 10P Brand Names Mixture

  • No information avaliable

Tecto 10P Chemical_Formula

C11H16N2O

Tecto 10P RX_link

http://www.rxlist.com/cgi/generic3/tocainide.htm

Tecto 10P fda sheet

Tecto 10P msds (material safety sheet)

Tecto 10P Synthesis Reference

No information avaliable

Tecto 10P Molecular Weight

192.258 g/mol

Tecto 10P Melting Point

246-266 oC

Tecto 10P H2O Solubility

1.07E+004 mg/L

Tecto 10P State

Solid

Tecto 10P LogP

1.308

Tecto 10P Dosage Forms

400 mg and 600 mg tablets for oral administration

Tecto 10P Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Tecto 10P Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Tecto 10P Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Tecto 10P side effects and Toxicity

The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Tecto 10P Patient Information

Tecto 10P Organisms Affected

Humans and other mammals