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Tubazole Brand names, Tubazole Analogs

Tubazole Brand Names Mixture

  • No information avaliable

Tubazole Chemical_Formula

C11H16N2O

Tubazole RX_link

http://www.rxlist.com/cgi/generic3/tocainide.htm

Tubazole fda sheet

Tubazole msds (material safety sheet)

Tubazole Synthesis Reference

No information avaliable

Tubazole Molecular Weight

192.258 g/mol

Tubazole Melting Point

246-266 oC

Tubazole H2O Solubility

1.07E+004 mg/L

Tubazole State

Solid

Tubazole LogP

1.308

Tubazole Dosage Forms

400 mg and 600 mg tablets for oral administration

Tubazole Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Tubazole Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Tubazole Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Tubazole side effects and Toxicity

The oral LD50 of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Tubazole Patient Information

Tubazole Organisms Affected

Humans and other mammals