Eprofil

Eprofil Brand names, Eprofil Analogs

Eprofil Brand Names Mixture

No information avaliable

Eprofil Chemical_Formula

C₁₁H₁₆N₂O

Eprofil RX_link

http://www.rxlist.com/cgi/generic3/tocainide.htm

Eprofil fda sheet

Eprofil msds (material safety sheet)

Eprofil Synthesis Reference

No information avaliable

Eprofil Molecular Weight

192.258 g/mol

Eprofil Melting Point

246-266 ^oC

Eprofil H₂O Solubility

1.07E+004 mg/L

Eprofil State

Solid

Eprofil LogP

1.308

Eprofil Dosage Forms

400 mg and 600 mg tablets for oral administration

Eprofil Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Eprofil Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Eprofil Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Eprofil side effects and Toxicity

The oral LD₅₀ of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Eprofil Patient Information

Eprofil Organisms Affected

Humans and other mammals