Mintesol

Mintesol Brand names, Mintesol Analogs

Mintesol Brand Names Mixture

No information avaliable

Mintesol Chemical_Formula

C₁₁H₁₆N₂O

Mintesol RX_link

http://www.rxlist.com/cgi/generic3/tocainide.htm

Mintesol fda sheet

Mintesol msds (material safety sheet)

Mintesol Synthesis Reference

No information avaliable

Mintesol Molecular Weight

192.258 g/mol

Mintesol Melting Point

246-266 ^oC

Mintesol H₂O Solubility

1.07E+004 mg/L

Mintesol State

Solid

Mintesol LogP

1.308

Mintesol Dosage Forms

400 mg and 600 mg tablets for oral administration

Mintesol Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Mintesol Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Mintesol Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Mintesol side effects and Toxicity

The oral LD₅₀ of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Mintesol Patient Information

Mintesol Organisms Affected

Humans and other mammals