Thiabenzole

Thiabenzole Brand names, Thiabenzole Analogs

Thiabenzole Brand Names Mixture

No information avaliable

Thiabenzole Chemical_Formula

C₁₁H₁₆N₂O

Thiabenzole RX_link

http://www.rxlist.com/cgi/generic3/tocainide.htm

Thiabenzole fda sheet

Thiabenzole msds (material safety sheet)

Thiabenzole Synthesis Reference

No information avaliable

Thiabenzole Molecular Weight

192.258 g/mol

Thiabenzole Melting Point

246-266 ^oC

Thiabenzole H₂O Solubility

1.07E+004 mg/L

Thiabenzole State

Solid

Thiabenzole LogP

1.308

Thiabenzole Dosage Forms

400 mg and 600 mg tablets for oral administration

Thiabenzole Indication

For the treatment of documented ventricular arrhythmias, such as sustained ventricular tachycardia, that, in the judgment of the physician, are life-threatening.

Thiabenzole Pharmacology

Tocainide is a primary amine analog of lidocaine with antiarrhythmic properties useful in the treatment of ventricular arrhythmias. Tocainide, like lidocaine, produces dose dependent decreases in sodium and potassium conductance, thereby decreasing the excitability of myocardial cells. In experimental animal models, the dose-related depression of sodium current is more pronounced in ischemic tissue than in normal tissue. Tocainide is a Class I antiarrhythmic compound with electrophysiologic properties in man similar to those of lidocaine, but dissimilar from quinidine, procainamide, and disopyramide.

Thiabenzole Absorption

Following oral administration, the bioavailability approaches 100 percent, and is unaffected by food.

Thiabenzole side effects and Toxicity

The oral LD₅₀ of tocainide was calculated to be about 800 mg/kg in mice, 1000 mg/kg in rats, and 230 mg/kg in guinea pigs; deaths were usually preceded by convulsions.

Thiabenzole Patient Information

Thiabenzole Organisms Affected

Humans and other mammals