HMD
Categorie
HMD Les marques, HMD Analogs
HMD Les marques melange
HMD Formule chimique
C10H14N2O4
HMD RX lien
http://www.rxlist.com/cgi/generic/sinemet.htm
HMD FDA fiche
HMD msds (fiche de securite des materiaux)
HMD Synthese de reference
Chemerda et al., US. 3,462,536 (1963)
HMD Poids moleculaire
226.229 g/mol
HMD Point de fusion
203-205oC
HMD H2O Solubilite
3,8 mg / L
HMD Etat
Solid
HMD LogP
0.494
HMD Formes pharmaceutiques
Comprimé (25 mg)
HMD Indication
Pour le traitement des symptômes de la maladie de Parkinson idiopathique (paralysie agitante), parkinsonisme post-encéphalitique
HMD Pharmacologie
Carbidopa, un inhibiteur de la décarboxylase non compétitif, est utilisé en combinaison avec la lévodopa pour le traitement de la maladie de Parkinson.
HMD Absorption
Rapidement décarboxylée à la dopamine dans les tissus extracérébrales sorte que seule une petite partie d'une dose donnée est transporté inchangées pour le système nerveux central.
HMD Toxicite
Les symptômes d'une toxicité carbidopa comprendre des spasmes musculaires ou une faiblesse, des spasmes de la paupière, des nausées, des vomissements, des diarrhées, un rythme cardiaque irrégulier, confusion, agitation, hallucinations, et l'inconscience.
HMD Information pour les patients
Carbidopa is used with levodopa to treat Parkinson's disease. Parkinson's disease
is believed to be related to low levels of a chemical called dopamine (DOE pa meen)
in the brain. Levodopa (Dopar, Larodopa) is turned into dopamine in the body.
Carbidopa is used with levodopa to prevent the breakdown (metabolism) of levodopa
before it can reach the brain and take effect. Carbidopa is only effective if it is
taken with levodopa. It has no effect if it is used alone. Carbidopa is used with
levodopa to treat the stiffness, tremors, spasms, and poor muscle control of
Parkinson's disease. These medications are also used to treat the same muscular
conditions when they are caused by drugs such as chlorpromazine (Thorazine),
fluphenazine (Prolixin), perphenazine (Trilafon), and others.
is believed to be related to low levels of a chemical called dopamine (DOE pa meen)
in the brain. Levodopa (Dopar, Larodopa) is turned into dopamine in the body.
Carbidopa is used with levodopa to prevent the breakdown (metabolism) of levodopa
before it can reach the brain and take effect. Carbidopa is only effective if it is
taken with levodopa. It has no effect if it is used alone. Carbidopa is used with
levodopa to treat the stiffness, tremors, spasms, and poor muscle control of
Parkinson's disease. These medications are also used to treat the same muscular
conditions when they are caused by drugs such as chlorpromazine (Thorazine),
fluphenazine (Prolixin), perphenazine (Trilafon), and others.
HMD Organismes affectes
Les humains et autres mammifères
