HMD
Categoria
HMD Nombres de marca, HMD Analogos
HMD Marca los nombres de mezcla
HMD Formula quimica
C10H14N2O4
HMD RX enlace
http://www.rxlist.com/cgi/generic/sinemet.htm
HMD FDA hoja
HMD MSDS (hoja de seguridad de materiales)
HMD Sintesis de referencia
Chemerda et al., Patente de EE.UU.. 3,462,536 (1963)
HMD Peso molecular
226.229 g/mol
HMD Punto de fusion
203-205oC
HMD H2O Solubilidad
3,8 mg / L
HMD Estado
Solid
HMD LogP
0.494
HMD Formas de dosificacion
Comprimido (25 mg)
HMD Indicacion
Para el tratamiento de los síntomas de la enfermedad de Parkinson idiopática (parálisis agitante), parkinsonismo postencefalítico
HMD Farmacologia
Carbidopa, un inhibidor de la descarboxilasa no competitivo, se utiliza en combinación con levodopa para el tratamiento de la enfermedad de Parkinson.
HMD Absorcion
Descarboxila rápidamente en dopamina en los tejidos extracerebrales de modo que sólo una pequeña parte de la dosis administrada es transportado sin cambios en el sistema nervioso central.
HMD Toxicidad
Los síntomas de una toxicidad carbidopa incluyen espasmos musculares o debilidad, espasmos de los párpados, náuseas, vómitos, diarrea, un latido irregular del corazón, confusión, agitación, alucinaciones y pérdida del conocimiento.
HMD Informacion de Pacientes
Carbidopa is used with levodopa to treat Parkinson's disease. Parkinson's disease
is believed to be related to low levels of a chemical called dopamine (DOE pa meen)
in the brain. Levodopa (Dopar, Larodopa) is turned into dopamine in the body.
Carbidopa is used with levodopa to prevent the breakdown (metabolism) of levodopa
before it can reach the brain and take effect. Carbidopa is only effective if it is
taken with levodopa. It has no effect if it is used alone. Carbidopa is used with
levodopa to treat the stiffness, tremors, spasms, and poor muscle control of
Parkinson's disease. These medications are also used to treat the same muscular
conditions when they are caused by drugs such as chlorpromazine (Thorazine),
fluphenazine (Prolixin), perphenazine (Trilafon), and others.
is believed to be related to low levels of a chemical called dopamine (DOE pa meen)
in the brain. Levodopa (Dopar, Larodopa) is turned into dopamine in the body.
Carbidopa is used with levodopa to prevent the breakdown (metabolism) of levodopa
before it can reach the brain and take effect. Carbidopa is only effective if it is
taken with levodopa. It has no effect if it is used alone. Carbidopa is used with
levodopa to treat the stiffness, tremors, spasms, and poor muscle control of
Parkinson's disease. These medications are also used to treat the same muscular
conditions when they are caused by drugs such as chlorpromazine (Thorazine),
fluphenazine (Prolixin), perphenazine (Trilafon), and others.
HMD Organismos afectados
Humanos y otros mamíferos
