Carbidopa Monohydrate
Carbidopa Monohydrate Brand names, Carbidopa Monohydrate Analogs
Carbidopa Monohydrate Brand Names Mixture
- Atamet (carbidopa + levodopa)
- Sinemet (carbidopa + levodopa)
Carbidopa Monohydrate Chemical_Formula
C10H14N2O4
Carbidopa Monohydrate RX_link
http://www.rxlist.com/cgi/generic/sinemet.htm
Carbidopa Monohydrate fda sheet
Carbidopa Monohydrate msds (material safety sheet)
Carbidopa Monohydrate Synthesis Reference
Chemerda et al., U.S. Pat. 3,462,536 (1963)
Carbidopa Monohydrate Molecular Weight
226.229 g/mol
Carbidopa Monohydrate Melting Point
203-205oC
Carbidopa Monohydrate H2O Solubility
3.8 mg/L
Carbidopa Monohydrate State
Solid
Carbidopa Monohydrate LogP
0.494
Carbidopa Monohydrate Dosage Forms
Tablet (25 mg)
Carbidopa Monohydrate Indication
For treatment of the symptoms of idiopathic Parkinson's disease (paralysis agitans), post-encephalitic parkinsonism
Carbidopa Monohydrate Pharmacology
Carbidopa, a noncompetitive decarboxylase inhibitor, is used in combination with levodopa for the treatment of Parkinson's disease.
Carbidopa Monohydrate Absorption
Rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system.
Carbidopa Monohydrate side effects and Toxicity
Symptoms of a carbidopa toxicity include muscle spasms or weakness, spasms of the eyelid, nausea, vomiting, diarrhea, an irregular heartbeat, confusion, agitation, hallucinations, and unconsciousness.
Carbidopa Monohydrate Patient Information
Carbidopa is used with levodopa to treat Parkinson's disease. Parkinson's disease
is believed to be related to low levels of a chemical called dopamine (DOE pa meen)
in the brain. Levodopa (Dopar, Larodopa) is turned into dopamine in the body.
Carbidopa is used with levodopa to prevent the breakdown (metabolism) of levodopa
before it can reach the brain and take effect. Carbidopa is only effective if it is
taken with levodopa. It has no effect if it is used alone. Carbidopa is used with
levodopa to treat the stiffness, tremors, spasms, and poor muscle control of
Parkinson's disease. These medications are also used to treat the same muscular
conditions when they are caused by drugs such as chlorpromazine (Thorazine),
fluphenazine (Prolixin), perphenazine (Trilafon), and others.
is believed to be related to low levels of a chemical called dopamine (DOE pa meen)
in the brain. Levodopa (Dopar, Larodopa) is turned into dopamine in the body.
Carbidopa is used with levodopa to prevent the breakdown (metabolism) of levodopa
before it can reach the brain and take effect. Carbidopa is only effective if it is
taken with levodopa. It has no effect if it is used alone. Carbidopa is used with
levodopa to treat the stiffness, tremors, spasms, and poor muscle control of
Parkinson's disease. These medications are also used to treat the same muscular
conditions when they are caused by drugs such as chlorpromazine (Thorazine),
fluphenazine (Prolixin), perphenazine (Trilafon), and others.
Carbidopa Monohydrate Organisms Affected
Humans and other mammals
