Lodosyn
Lodosyn Brand names, Lodosyn Analogs
Lodosyn Brand Names Mixture
- Atamet (carbidopa + levodopa)
- Sinemet (carbidopa + levodopa)
Lodosyn Chemical_Formula
C10H14N2O4
Lodosyn RX_link
http://www.rxlist.com/cgi/generic/sinemet.htm
Lodosyn fda sheet
Lodosyn msds (material safety sheet)
Lodosyn Synthesis Reference
Chemerda et al., U.S. Pat. 3,462,536 (1963)
Lodosyn Molecular Weight
226.229 g/mol
Lodosyn Melting Point
203-205oC
Lodosyn H2O Solubility
3.8 mg/L
Lodosyn State
Solid
Lodosyn LogP
0.494
Lodosyn Dosage Forms
Tablet (25 mg)
Lodosyn Indication
For treatment of the symptoms of idiopathic Parkinson's disease (paralysis agitans), post-encephalitic parkinsonism
Lodosyn Pharmacology
Carbidopa, a noncompetitive decarboxylase inhibitor, is used in combination with levodopa for the treatment of Parkinson's disease.
Lodosyn Absorption
Rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system.
Lodosyn side effects and Toxicity
Symptoms of a carbidopa toxicity include muscle spasms or weakness, spasms of the eyelid, nausea, vomiting, diarrhea, an irregular heartbeat, confusion, agitation, hallucinations, and unconsciousness.
Lodosyn Patient Information
Carbidopa is used with levodopa to treat Parkinson's disease. Parkinson's disease
is believed to be related to low levels of a chemical called dopamine (DOE pa meen)
in the brain. Levodopa (Dopar, Larodopa) is turned into dopamine in the body.
Carbidopa is used with levodopa to prevent the breakdown (metabolism) of levodopa
before it can reach the brain and take effect. Carbidopa is only effective if it is
taken with levodopa. It has no effect if it is used alone. Carbidopa is used with
levodopa to treat the stiffness, tremors, spasms, and poor muscle control of
Parkinson's disease. These medications are also used to treat the same muscular
conditions when they are caused by drugs such as chlorpromazine (Thorazine),
fluphenazine (Prolixin), perphenazine (Trilafon), and others.
is believed to be related to low levels of a chemical called dopamine (DOE pa meen)
in the brain. Levodopa (Dopar, Larodopa) is turned into dopamine in the body.
Carbidopa is used with levodopa to prevent the breakdown (metabolism) of levodopa
before it can reach the brain and take effect. Carbidopa is only effective if it is
taken with levodopa. It has no effect if it is used alone. Carbidopa is used with
levodopa to treat the stiffness, tremors, spasms, and poor muscle control of
Parkinson's disease. These medications are also used to treat the same muscular
conditions when they are caused by drugs such as chlorpromazine (Thorazine),
fluphenazine (Prolixin), perphenazine (Trilafon), and others.
Lodosyn Organisms Affected
Humans and other mammals
