N-Aminomethyldopa en es it fr

N-Aminomethyldopa Brand names, N-Aminomethyldopa Analogs

N-Aminomethyldopa Brand Names Mixture

  • Atamet (carbidopa + levodopa)
  • Sinemet (carbidopa + levodopa)

N-Aminomethyldopa Chemical_Formula


N-Aminomethyldopa RX_link


N-Aminomethyldopa fda sheet

N-Aminomethyldopa msds (material safety sheet)

N-Aminomethyldopa Synthesis Reference

Chemerda et al., U.S. Pat. 3,462,536 (1963)

N-Aminomethyldopa Molecular Weight

226.229 g/mol

N-Aminomethyldopa Melting Point


N-Aminomethyldopa H2O Solubility

3.8 mg/L

N-Aminomethyldopa State


N-Aminomethyldopa LogP


N-Aminomethyldopa Dosage Forms

Tablet (25 mg)

N-Aminomethyldopa Indication

For treatment of the symptoms of idiopathic Parkinson's disease (paralysis agitans), post-encephalitic parkinsonism

N-Aminomethyldopa Pharmacology

Carbidopa, a noncompetitive decarboxylase inhibitor, is used in combination with levodopa for the treatment of Parkinson's disease.

N-Aminomethyldopa Absorption

Rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system.

N-Aminomethyldopa side effects and Toxicity

Symptoms of a carbidopa toxicity include muscle spasms or weakness, spasms of the eyelid, nausea, vomiting, diarrhea, an irregular heartbeat, confusion, agitation, hallucinations, and unconsciousness.

N-Aminomethyldopa Patient Information

Carbidopa is used with levodopa to treat Parkinson's disease. Parkinson's disease
is believed to be related to low levels of a chemical called dopamine (DOE pa meen)
in the brain. Levodopa (Dopar, Larodopa) is turned into dopamine in the body.
Carbidopa is used with levodopa to prevent the breakdown (metabolism) of levodopa
before it can reach the brain and take effect. Carbidopa is only effective if it is
taken with levodopa. It has no effect if it is used alone. Carbidopa is used with
levodopa to treat the stiffness, tremors, spasms, and poor muscle control of
Parkinson's disease. These medications are also used to treat the same muscular
conditions when they are caused by drugs such as chlorpromazine (Thorazine),
fluphenazine (Prolixin), perphenazine (Trilafon), and others.

N-Aminomethyldopa Organisms Affected

Humans and other mammals