Atamet
Atamet Brand names, Atamet Analogs
Atamet Brand Names Mixture
- Atamet (carbidopa + levodopa)
- Sinemet (carbidopa + levodopa)
Atamet Chemical_Formula
C10H14N2O4
Atamet RX_link
http://www.rxlist.com/cgi/generic/sinemet.htm
Atamet fda sheet
Atamet msds (material safety sheet)
Atamet Synthesis Reference
Chemerda et al., U.S. Pat. 3,462,536 (1963)
Atamet Molecular Weight
226.229 g/mol
Atamet Melting Point
203-205oC
Atamet H2O Solubility
3.8 mg/L
Atamet State
Solid
Atamet LogP
0.494
Atamet Dosage Forms
Tablet (25 mg)
Atamet Indication
For treatment of the symptoms of idiopathic Parkinson's disease (paralysis agitans), post-encephalitic parkinsonism
Atamet Pharmacology
Carbidopa, a noncompetitive decarboxylase inhibitor, is used in combination with levodopa for the treatment of Parkinson's disease.
Atamet Absorption
Rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system.
Atamet side effects and Toxicity
Symptoms of a carbidopa toxicity include muscle spasms or weakness, spasms of the eyelid, nausea, vomiting, diarrhea, an irregular heartbeat, confusion, agitation, hallucinations, and unconsciousness.
Atamet Patient Information
Carbidopa is used with levodopa to treat Parkinson's disease. Parkinson's disease
is believed to be related to low levels of a chemical called dopamine (DOE pa meen)
in the brain. Levodopa (Dopar, Larodopa) is turned into dopamine in the body.
Carbidopa is used with levodopa to prevent the breakdown (metabolism) of levodopa
before it can reach the brain and take effect. Carbidopa is only effective if it is
taken with levodopa. It has no effect if it is used alone. Carbidopa is used with
levodopa to treat the stiffness, tremors, spasms, and poor muscle control of
Parkinson's disease. These medications are also used to treat the same muscular
conditions when they are caused by drugs such as chlorpromazine (Thorazine),
fluphenazine (Prolixin), perphenazine (Trilafon), and others.
is believed to be related to low levels of a chemical called dopamine (DOE pa meen)
in the brain. Levodopa (Dopar, Larodopa) is turned into dopamine in the body.
Carbidopa is used with levodopa to prevent the breakdown (metabolism) of levodopa
before it can reach the brain and take effect. Carbidopa is only effective if it is
taken with levodopa. It has no effect if it is used alone. Carbidopa is used with
levodopa to treat the stiffness, tremors, spasms, and poor muscle control of
Parkinson's disease. These medications are also used to treat the same muscular
conditions when they are caused by drugs such as chlorpromazine (Thorazine),
fluphenazine (Prolixin), perphenazine (Trilafon), and others.
Atamet Organisms Affected
Humans and other mammals
