Carbidopa-Levodopa en es it fr

Carbidopa-Levodopa Brand names, Carbidopa-Levodopa Analogs

Carbidopa-Levodopa Brand Names Mixture

  • Atamet (carbidopa + levodopa)
  • Sinemet (carbidopa + levodopa)

Carbidopa-Levodopa Chemical_Formula


Carbidopa-Levodopa RX_link

Carbidopa-Levodopa fda sheet

Carbidopa-Levodopa msds (material safety sheet)

Carbidopa-Levodopa Synthesis Reference

Chemerda et al., U.S. Pat. 3,462,536 (1963)

Carbidopa-Levodopa Molecular Weight

226.229 g/mol

Carbidopa-Levodopa Melting Point


Carbidopa-Levodopa H2O Solubility

3.8 mg/L

Carbidopa-Levodopa State


Carbidopa-Levodopa LogP


Carbidopa-Levodopa Dosage Forms

Tablet (25 mg)

Carbidopa-Levodopa Indication

For treatment of the symptoms of idiopathic Parkinson's disease (paralysis agitans), post-encephalitic parkinsonism

Carbidopa-Levodopa Pharmacology

Carbidopa, a noncompetitive decarboxylase inhibitor, is used in combination with levodopa for the treatment of Parkinson's disease.

Carbidopa-Levodopa Absorption

Rapidly decarboxylated to dopamine in extracerebral tissues so that only a small portion of a given dose is transported unchanged to the central nervous system.

Carbidopa-Levodopa side effects and Toxicity

Symptoms of a carbidopa toxicity include muscle spasms or weakness, spasms of the eyelid, nausea, vomiting, diarrhea, an irregular heartbeat, confusion, agitation, hallucinations, and unconsciousness.

Carbidopa-Levodopa Patient Information

Carbidopa is used with levodopa to treat Parkinson's disease. Parkinson's disease
is believed to be related to low levels of a chemical called dopamine (DOE pa meen)
in the brain. Levodopa (Dopar, Larodopa) is turned into dopamine in the body.
Carbidopa is used with levodopa to prevent the breakdown (metabolism) of levodopa
before it can reach the brain and take effect. Carbidopa is only effective if it is
taken with levodopa. It has no effect if it is used alone. Carbidopa is used with
levodopa to treat the stiffness, tremors, spasms, and poor muscle control of
Parkinson's disease. These medications are also used to treat the same muscular
conditions when they are caused by drugs such as chlorpromazine (Thorazine),
fluphenazine (Prolixin), perphenazine (Trilafon), and others.

Carbidopa-Levodopa Organisms Affected

Humans and other mammals