Valacyclovir
Valacyclovir Brand names, Valacyclovir Analogs
Valacyclovir Brand Names Mixture
- No information avaliable
Valacyclovir Chemical_Formula
C13H20N6O4
Valacyclovir RX_link
http://www.rxlist.com/cgi/generic3/valacyclovir.htm
Valacyclovir fda sheet
Valacyclovir msds (material safety sheet)
Valacyclovir Synthesis Reference
No information avaliable
Valacyclovir Molecular Weight
324.336 g/mol
Valacyclovir Melting Point
No information avaliable
Valacyclovir H2O Solubility
No information avaliable
Valacyclovir State
Solid
Valacyclovir LogP
No information avaliable
Valacyclovir Dosage Forms
Tablet
Valacyclovir Indication
For the treatment or suppression of cold sores (herpes labialis), herpes zoster (shingles), genital herpes in immunocompetent individuals, and recurrent genital herpes in HIV-infected individuals.
Valacyclovir Pharmacology
Valacyclovir is a prodrug and synthetic purine nucleoside analogue with inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV). Valacyclovir is almost completely converted to acyclovir and L-valine. The inhibitory activity of valacyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, which is then converted into acyclovir diphosphate and triphosphate by cellular enzymes. Acyclovir is selectively converted to the active triphosphate form by cells infected with herpes viruses.
Valacyclovir Absorption
After oral administration, valacyclovir hydrochloride is rapidly absorbed from the gastrointestinal tract. The absolute bioavailability of acyclovir after administration of valacyclovir is 54.5% ± 9.1%.
Valacyclovir side effects and Toxicity
Adverse effects of overexposure might include headache and nausea.
Valacyclovir Patient Information
Valacyclovir Organisms Affected
Human herpes virus
